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Bexarotene - Potential COVID-19 treatments with recent research
Since the outbreak of the Coronavirus Disease 2019(COVID-19), many parties around the world are looking for the effective drugs to treat the disease. The latest research found that Bexarotene showed significant efficacy in the COVID-19 treatment. A few clinically approved drugs, such as remdesivir, chloroquine, hydroxychloroquine, nafamostat, camostat, and ivermectin, exhibited anti-SARS-CoV-2 activity in vitro and/or in a small number of patients. However, their clinical use may be limited by anti-SARS-CoV-2 50 % maximal effective concentrations (EC50) that exceeded their achievable peak serum concentrations (Cmax), side effects, and/or availability. To find more immediately available COVID-19 antivirals. The Author established a two-tier drug screening system that combines SARS-CoV-2 enzyme-linked immunosorbent assay and cell viability assay, and applied it to screen a library consisting 1528 FDA-approved drugs. Cetilistat (anti-pancreatic lipase), diiodohydroxyquinoline (anti-parasitic), abirateroneacetate (synthetic androstane steroid), and bexarotene (antineoplastic retinoid) exhibited potent in vitro anti-SARS-CoV-2 activity (EC501.13–2.01μM). Bexarotene demonstrated the highest Cmax: EC50 ratio (1.69) which was higher than those of chloroquine, hydroxychloroquine. Article:Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline, and abiraterone as potential COVID-19 treatments with a robust two-tier screening system
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Since the outbreak of the Coronavirus Disease 2019(COVID-19), many parties around the world are looking for the effective drugs to treat the disease. The latest research found that Bexarotene showed significant efficacy in the COVID-19 treatment. A few clinically approved drugs, such as remdesivir, chloroquine, hydroxychloroquine, nafamostat, camostat, and ivermectin, exhibited anti-SARS-CoV-2 activity in vitro and/or in a small number of patients. However, their clinical use may be limited by anti-SARS-CoV-2 50 % maximal effective concentrations (EC50) that exceeded their achievable peak serum concentrations (Cmax), side effects, and/or availability. To find more immediately available COVID-19 antivirals. The Author established a two-tier drug screening system that combines SARS-CoV-2 enzyme-linked immunosorbent assay and cell viability assay, and applied it to screen a library consisting 1528 FDA-approved drugs. Cetilistat (anti-pancreatic lipase), diiodohydroxyquinoline (anti-parasitic), abirateroneacetate (synthetic androstane steroid), and bexarotene (antineoplastic retinoid) exhibited potent in vitro anti-SARS-CoV-2 activity (EC501.13–2.01μM). Bexarotene demonstrated the highest Cmax: EC50 ratio (1.69) which was higher than those of chloroquine, hydroxychloroquine. Article:Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline, and abiraterone as potential COVID-19 treatments with a robust two-tier screening system
Effect of Ruxolitinib phosphate on COVID-19
April 2, 2020, Novartis announces plan to initiate clinical study of Ruxolitinib in severe COVID-19 patients and establish international compassionate use program. Patients with COVID-19 can lead to life-threatening respiratory complications due to cytokine storm. Pre-clinical and preliminary clinical evidence suggests Ruxolitinib could reduce the cytokine storm syndromes. In Italy, 7 severe COVID-19 patients in ICU accept Ruxolitinib treatment and getting better, after two days treatment, 5 patients do not need ventilator anymore. In China, Novartis also apply Ruxolitinib clinical study to treat COVID-19. Chongqing Huapont Pharmaceutical Co., Ltd. started to develop Ruxolitinib since 2014, submitted DMF#29480 to USFDA and paid GUDFA fee in 2015. In order to fight against COVID-19 and protect human beings health, Huapont commit to do our best for keeping effective supply Ruxolitinib API.
See more information
April 2, 2020, Novartis announces plan to initiate clinical study of Ruxolitinib in severe COVID-19 patients and establish international compassionate use program. Patients with COVID-19 can lead to life-threatening respiratory complications due to cytokine storm. Pre-clinical and preliminary clinical evidence suggests Ruxolitinib could reduce the cytokine storm syndromes. In Italy, 7 severe COVID-19 patients in ICU accept Ruxolitinib treatment and getting better, after two days treatment, 5 patients do not need ventilator anymore. In China, Novartis also apply Ruxolitinib clinical study to treat COVID-19. Chongqing Huapont Pharmaceutical Co., Ltd. started to develop Ruxolitinib since 2014, submitted DMF#29480 to USFDA and paid GUDFA fee in 2015. In order to fight against COVID-19 and protect human beings health, Huapont commit to do our best for keeping effective supply Ruxolitinib API.
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