• Categories:2020
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• Time of issue:2020-06-29 10:20
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【Summary】Since the outbreak of the Coronavirus Disease 2019(COVID-19), many parties around the world are looking for the effective drugs to treat the disease. The latest research found that Bexarotene showed significant efficacy in the COVID-19 treatment.

A few clinically approved drugs, such as remdesivir, chloroquine, hydroxychloroquine, nafamostat, camostat, and ivermectin, exhibited anti-SARS-CoV-2 activity in vitro and/or in a small number of patients. However, their clinical use may be limited by anti-SARS-CoV-2 50 % maximal effective concentrations (EC50) that exceeded their achievable peak serum concentrations (Cmax), side effects, and/or availability. To find more immediately available COVID-19 antivirals. The Author established a two-tier drug screening system that combines SARS-CoV-2 enzyme-linked immunosorbent assay and cell viability assay, and applied it to screen a library consisting 1528 FDA-approved drugs. Cetilistat (anti-pancreatic lipase), diiodohydroxyquinoline (anti-parasitic), abirateroneacetate (synthetic androstane steroid), and bexarotene (antineoplastic retinoid) exhibited potent in vitro anti-SARS-CoV-2 activity (EC501.13–2.01μM). Bexarotene demonstrated the highest Cmax: EC50 ratio (1.69) which was higher than those of chloroquine, hydroxychloroquine.

Article：Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline, and abiraterone as potential COVID-19 treatments with a robust two-tier screening system